Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8814639 | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | 2017 | 45 Pages |
Abstract
There is a cumulative deleterious effect of LOAD risk genes on hippocampal function even in healthy volunteers. The effect of LOAD-RPS on hippocampal function in the relative absence of any effect on cognitive and morphometric measures is consistent with the reported temporal characteristics of LOAD biomarkers with the earlier manifestation of synaptic dysfunction before morphometric and cognitive changes.
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Ena Xiao, Qiang Chen, Aaron L. Goldman, Hao Yang Tan, Kaitlin Healy, Brad Zoltick, Saumitra Das, Bhaskar Kolachana, Joseph H. Callicott, Dwight Dickinson, Karen F. Berman, Daniel R. Weinberger, Venkata S. Mattay,