Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8815514 | Journal of Affective Disorders | 2018 | 23 Pages |
Abstract
Polygenic risk scores for BD and MDD are associated with a range of phenotypes and outcomes. However, they only explain a small amount of the variation in these phenotypes. Larger discovery and adequately powered target samples are required to increase power of the PRS approach. This could elucidate how genetic risk for bipolar disorder and depression is manifest and contribute meaningfully to stratified medicine.
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Authors
Sumit Mistry, Judith R. Harrison, Daniel J. Smith, Valentina Escott-Price, Stanley Zammit,