| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8815640 | Journal of Affective Disorders | 2018 | 47 Pages |
Abstract
This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naïve MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted.
Keywords
SCIDMDDLC-MSLDL-CLPCFIBLPElysophosphatidylethanolamineHDL-CIDOTDOIL-6BDI-IIBeck Depression Inventory-Second EditionhsCRPAUCT-BILMajor depressive disorderUric acidinterleukin-6indoleamine 2,3-dioxygenaseBlood biomarkerstriacylglycerolTryptophan 2,3-dioxygenasetumor necrosis factor-αSODbody mass indexBMISeverity of depressionLiquid chromatography-mass spectrometryTNF-αphosphatidylcholinephosphatidylethanolamineFibrinogenLysophosphatidylcholineLow density lipoprotein-cholesterolHigh density lipoprotein-cholesterolROC curveReceiver operating characteristic curvearea under the curvehigh-sensitivity C-reactive proteincholesteryl estercholesteryl esterstotal-cholesterolhealthy controls
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Authors
Nobuki Kuwano, Takahiro A. Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba,