The effects of vortioxetine on cognitive performance in working patients with major depressive disorder: A short-term, randomized, double-blind, exploratory study

Article ID	Journal	Published Year	Pages	File Type
8815753	Journal of Affective Disorders	2018	33 Pages	PDF

Abstract

This explorative study showed no significant differences versus placebo in DSST or UPSA-B performance at week 8. However, secondary results support vortioxetine as an effective and well-tolerated antidepressant, supporting an added benefit for cognition and functioning, which could have particular therapeutic relevance for the working patient population.

Keywords

LOCF sRT DSST MADRS DSM-IV-TR CGI-I CGI-S C-CASA MDD ANCOVA FAS Crt TMT-A TMT-B C-SSRS MMRM TEAE Clinical trials SES Major depressive disorder Stroop standard deviation Standardized Effect Size analysis of covariance digit symbol substitution test standard error Antidepressants treatment emergent adverse event Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision Choice reaction time Simple reaction time FAST Cognition last observation carried forward Columbia Suicide Severity Rating Scale selective serotonin reuptake inhibitors SSRI Least squares