Efficacy of adjunctive brexpiprazole on the core symptoms of major depressive disorder: A post hoc analysis of two pooled clinical studies

Article ID	Journal	Published Year	Pages	File Type
8815846	Journal of Affective Disorders	2018	23 Pages	PDF

Abstract

Brexpiprazole, as adjunct to ADT, produced a statistically significant and clinically meaningful improvement on the core symptoms of MDD. Brexpiprazole is thought to exert its effects in MDD by treating the core symptoms of the disease.

Keywords

ADT MMRM Core symptoms HAM-D17 ANCOVA CGI-I MDD Brexpiprazole HAM-D DSM-IV-TR MADRS TEAE Major depressive disorder Depression Extended release standard deviation Item analysis analysis of covariance standard error Antipsychotic Antidepressant treatment Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision body mass index BMI treatment-emergent adverse event Montgomery–Åsberg Depression Rating Scale Hamilton Depression Rating Scale Least squares