Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8817559 | Biomedical and Environmental Sciences | 2017 | 5 Pages |
Abstract
The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.
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Authors
Cheng WANG, Jun LI, Guan Ling SONG, Qiang NIU, Shang Zhi XU, Gang Ling FENG, Hai Xia WANG, Yu LI, Shu Gang LI, Feng LI,