| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8817573 | Biomedical and Environmental Sciences | 2017 | 5 Pages |
Abstract
Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula (PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins (BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis (PFGE) revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated by type B C. botulinum spores.
Related Topics
Health Sciences
Medicine and Dentistry
Public Health and Health Policy
Authors
Yin Ping DONG, Wei WANG, Tao JIANG, Jin XU, Chun Hui HAN, Shao Fei YAN, Séamus Fanning, Ying LI, Xiao Chen MA, Di ZHANG, Yao ZHAO, Biao ZENG, Feng Qin LI,