| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8817694 | Biomedical and Environmental Sciences | 2016 | 4 Pages |
Abstract
Rats were exposed to 1 or 10 µg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.
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Authors
Liang GAO, Han Ning WANG, Ling ZHANG, Fang Yuan PENG, Yue JIA, Wei WEI, Li Hong JIA,