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Ivacaftor restores CFTR-dependent sweat gland fluid secretion in cystic fibrosis subjects with S945L alleles

Article ID Journal Published Year Pages File Type
8819623 Journal of Cystic Fibrosis 2018 7 Pages PDF
Abstract
These in vivo results, consistent with prior in vitro findings, indicate that the drug treatments restore near-normal function to S945L-CFTR, and support the use of ivacaftor as a treatment for CF patients who carry this allele.
Keywords
CFTR modulatorsSweat rate
Related Topics
Health Sciences Medicine and Dentistry Pulmonary and Respiratory Medicine
Preview
Ivacaftor restores CFTR-dependent sweat gland fluid secretion in cystic fibrosis subjects with S945L alleles
Authors
Jeeyeon Kim, Zoe Davies, Colleen Dunn, Jeffrey J. Wine, Carlos Milla,
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