Article ID Journal Published Year Pages File Type
8819794 Journal of Cystic Fibrosis 2017 4 Pages PDF
Abstract
The combination of lumacaftor and ivacaftor (LUM/IVA) has been reported to induce a mean acute absolute drop of − 4.1% predicted forced expiratory volume in 1 s (FEV1) after a unique administration in healthy subjects. The aim of the present study was to assess acute FEV1 changes after the first dose of LUM/IVA in CF patients. A total of 32 pediatric patients were included. Respiratory manifestations occurred in only 3 patients (9.4%), but FEV1 consistently decreased (− 10.4 ± 4.6%, range: − 1.5; − 21.8%). FEV1 only partially resumed after salbutamol inhalation. Patients with previously known significant reversible airway obstruction and low FEV1 were more at risk of FEV1 decrease.
Related Topics
Health Sciences Medicine and Dentistry Pulmonary and Respiratory Medicine
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