Les traitements péri-opératoires des carcinomes bronchiques non à petites cellules

Innovative treatments which have demonstrated activity in advanced disease have been evaluated in the perioperative setting. Antiangiogenic agents have no interest in this situation. Studies of EGFR tyrosine kinase inhibitors in all-comers are negative. The first phase lll results of adjuvant EGFR tyrosine kinase inhibitors in EGFR-mutated tumors are promising. Preliminary data of immune checkpoint inhibitors given as neoadjuvant therapy highly justify further study. Several ongoing large trials should help to better define the place of these agents within the future therapeutic perioperative panel.