Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8822691 | European Journal of Radiology | 2018 | 5 Pages |
Abstract
The repetitive application of transcranial magnetic stimulation (rTMS) on left dorsolateral prefrontal cortex (DLPFC) has been consistently shown to be beneficial for treating various neuropsychiatric or neuropsychological disorders, but its neural mechanisms still remain unclear. The purpose of this study was to measure the effects of high-frequency left DLPFC rTMS using cerebral blood flow (CBF) collected from 40 young healthy subjects before and after applying 20â¯Hz left DLPFC rTMS or SHAM stimulations. Relative CBF (rCBF) changes before and after 20â¯Hz rTMS or SHAM were assessed with paired-t test. The results show that 20â¯Hz DLPFC rTMS induced CBF redistribution in the default mode network, including increased rCBF in left medial temporal cortex (MTC)/hippocampus, but reduced rCBF in precuneus and cerebellum. Meanwhile, SHAM stimulation didn't produce any rCBF changes. After controlling SHAM effects, only the rCBF increase in MTC/hippocampus remained. Those data suggest that the beneficial effects of high-frequency rTMS may be through a within-network rCBF redistribution.
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Authors
Yuan-Qi Shang, Jun Xie, Wei Peng, Jian Zhang, Da Chang, Ze Wang,