| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8833573 | Journal of the American College of Surgeons | 2018 | 24 Pages |
Abstract
We identify BACH2 as a susceptibility locus for postoperative recurrence of Crohn's disease in our cohort. BACH2 is critical in the differentiation and function of T cells, as a regulator of B-cell activity, and is associated with several dysregulated immunologic phenomena. Its identification as a risk locus in postoperative Crohn's disease recurrence suggests a potential role for regulatory T cells, effector T cells, humoral immunity, and immunologic memory in the development of this disease process.
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Authors
Michael R. MD, Richard N. MD, Eytan MD, PhD, Bryan MD, Karen L. PhD,