Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8835560 | Journal of Surgical Research | 2018 | 13 Pages |
Abstract
Cecal abrasion in mice is a reliable model to study abdominal adhesions, which can be ameliorated using the MEK1/2 inhibitor trametinib. While blocking adhesion formation at the cell and molecular levels, trametinib, at the therapeutic doses utilized, did not impair the wound healing at the laparotomy site.
Keywords
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Authors
Edward J. PhD, Christine E. MD, Deepika MD, Xiaoling MD, PhD, Peter J. PhD, Anna-Karin MD, Matthew BS, Joel MD, PhD,