Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8835646 | Journal of Surgical Research | 2018 | 7 Pages |
Abstract
Increased expression of zonula occludens-1, occludin, and cyclooxygenase-2 suggested a greater regenerative effort because of more severe lesions in the saline group. In addition, increased expression of interleukin-6 in the saline group was suggestive of inflammation, indicating that diazoxide had protective effects in the diazoxide group. Reduced aspartate aminotransferase in the diazoxide group suggested liver protection. Diazoxide protects the intestines and liver from intestinal ischemia reperfusion lesions in rats.
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Authors
Saulo MD, Denise Frediani PhD, Marcia Kiyomi PhD, Hermes Vieira PhD, Fabiano MD, PhD, Marcel Cerqueira MD, PhD,