Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8835694 | Journal of Surgical Research | 2018 | 4 Pages |
Abstract
Subcutaneous administration of cefazolin achieves a significantly lower maximum serum concentration than IV injection. As a result, higher doses of antibiotic can be injected locally without incurring systemic toxicity. Subcutaneous administration will therefore result in higher concentrations of antibiotic for a longer time at the incision site compared with standard IV administration. This strategy of antibiotic delivery may be more effective in preventing SSIs. Further studies are needed to detail the exact effect of subcutaneous antibiotic injection on SSI rates.
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Authors
Genia MD, Nhan MD, Joshua D. MD, John P. PhD, David P. PharmD, FCCP, FIDSA, Christina A. BS, Seth PhD, James C.Y. MD, PhD,