Article ID Journal Published Year Pages File Type
8835694 Journal of Surgical Research 2018 4 Pages PDF
Abstract
Subcutaneous administration of cefazolin achieves a significantly lower maximum serum concentration than IV injection. As a result, higher doses of antibiotic can be injected locally without incurring systemic toxicity. Subcutaneous administration will therefore result in higher concentrations of antibiotic for a longer time at the incision site compared with standard IV administration. This strategy of antibiotic delivery may be more effective in preventing SSIs. Further studies are needed to detail the exact effect of subcutaneous antibiotic injection on SSI rates.
Related Topics
Health Sciences Medicine and Dentistry Surgery
Authors
, , , , , , , , , , ,