Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8836642 | Surgery | 2018 | 12 Pages |
Abstract
Taken together, these data suggest that GDF11 and its downstream signals are critical in vivo mediators of renal injury. These effects are through direct actions of GDF11 on renal tubular cells and fibroblasts. Thus, regulation of GDF11 presents a therapeutic target for diseases involving renal fibrosis and impaired tubular function.
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Authors
Marianne PhD, Leonidas G. MD, Sharon M. MD, Juan C. MD, Aurora PhD, Teresa A. PhD,