Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies

- A new line of mice,Val68Met, mimic human BDNF Val66Met polymorphism.
- New knock-in BDNF Met mice reverse more efficiently than Val in two separate tasks.
- Supports theory that BDNF Met allele confers greater sensitivity to the environment.
- Reversal performance can be dissociated from go/no-go and extinction performance.
- Phenotypes differ between newer and older BDNF Val66Met mouse models.