Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8838879 | Brain Research Bulletin | 2018 | 8 Pages |
Abstract
This study demonstrates that sevoflurane may induce hippocampal neuron autophagy in primary cultured hippocampal neuronal cell and that Beclin-1 and Atg5 are involved in the process of sevoflurane-induced autophagy. Exposure of sevoflurane may not only induce autophagy of hippocampal neurons but also activate the apoptosis of hippocampal neurons. Autophagy may play an important role in sevoflurane-induced neurotoxicity in primary cultured hippocampal neuronal cells.
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Authors
Lili Xu, Jianjun Shen, Lina Yu, Jianliang Sun, Patrick M. McQuillan, Zhiyong Hu, Min Yan,