| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8838904 | Brain Research Bulletin | 2018 | 10 Pages |
Abstract
Our novel findings shed new light on the role of GDF11. Our results strongly suggest that GDF11 improves neurofunctional recovery from cerebral I/R injury and that this effect is mediated partly through its proangiogenic effect in the peri-infarct cerebral cortex, which is associated with ALK5. Thus, GDF11/ALK5 may represent new therapeutic targets for aiding recovery from stroke.
Keywords
rCBFMCAFITCGAPDHEPCsTGF-βMCAO/RGDF11mNSSactivin-like kinase 5ALK5ECsI/RAngiogenesismiddle cerebral artery occlusion/reperfusionischemia/reperfusioncerebral ischemia/reperfusiontransforming growth factor-βsecondsRegional cerebral blood flowdaysEndothelial progenitor cellsEndothelial cellsmiddle cerebral arterygrowth differentiation factor 11fluorescein isothiocyanateglyceraldehyde 3-phosphate dehydrogenase
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Authors
Jingxi Ma, Lina Zhang, Tengfei Niu, Chibo Ai, Gongwei Jia, Xinhao Jin, Lan Wen, Keming Zhang, Qinbin Zhang, Changqing Li,