Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8838966 | Brain Research Bulletin | 2018 | 5 Pages |
Abstract
To determine the effects of auditory stimulus on skin conductance (SC) in infants with severe neonatal abstinence syndrome (NAS) that required morphine treatment (MT) compared with NAS infants that did not require morphine treatment (non-MT). We prospectively enrolled opiate-exposed term infants without polysubstance exposure. Skin conductance responses to an auditory stimulus (ringing a bell for 3Â s) near the time of discharge were obtained. Skin conductance was measured before, during, and after the stimulus. Non-parametric tests were used to determine between group and within phase differences. Infants were off MT at the time of SC measurement in response to an auditory stimulus. In a 2-group comparison of MT vs. non-MT infants, there was significantly higher SC responsivity to an auditory stimulus (p <Â 0.05) in the MT group as compared with the non-MT group near discharge. The mean +SE peak morphine dose was 0.85Â +Â 0.20Â mg/kg/day in the MT group. The mean Length of Stay (LOS) was 32 vs. 7 (p <Â 0.05) days respectively, for the MT vs. the non-MT group. Our preliminary data suggest that in infants with severe NAS symptoms, higher sympathetic arousal in response to an auditory stimulus persists at discharge, underscoring the need for ongoing evaluation and specialized care at home.
Keywords
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Christiana N Oji-Mmuo, Fumiyuki Chin Gardner, Kim K Doheny,