Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8839644 | Brain Research | 2018 | 38 Pages |
Abstract
Aldosterone infusion into the 4th ventricle (4th V), upstream the nucleus of the solitary tract (NTS), produces strong 0.3â¯M NaCl intake. In the present study, we investigated whether aldosterone infusion into the 4th V activates HSD2 neurons, changes renal excretion, or alters blood pressure and cardiovascular reflexes. Chronic infusion of aldosterone (100â¯ng/h) into the 4th V increased daily 0.3â¯M NaCl intake (up to 44â¯Â±â¯10, vs. vehicle: 5.6â¯Â±â¯3.4â¯ml/24â¯h) and also c-Fos expression in HSD2 neurons in the NTS and in non-HSD2 neurons in the NTS. Natriuresis, diuresis and positive sodium balance were present in rats that ingested 0.3â¯M NaCl, however, renal excretion was not modified by 4th V aldosterone in rats that had no access to NaCl. 4th V aldosterone also reduced baroreflex sensitivity (â2.8â¯Â±â¯0.5, vs. vehicle: â5.1â¯Â±â¯0.9â¯bpm/mmHg) in animals that had sodium available, without changing blood pressure. The results suggest that sodium intake induced by aldosterone infused into the 4th V is associated with activation of NTS neurons, among them the HSD2 neurons. Aldosterone infused into the 4th V in association with sodium intake also impairs baroreflex sensitivity, without changing arterial pressure.
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Authors
S. Gasparini, M.R. Melo, G.M.F. Andrade-Franzé, J.C. Geerling, J.V. Menani, E. Colombari,