Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8839656 | Brain Research | 2018 | 42 Pages |
Abstract
In the central nervous system (CNS), extracellular matrix (ECM) molecules comprise more than 20% of the volume and are involved in neuronal plasticity, synaptic transmission, and differentiation. Perineuronal nets (PNNs) are ECM molecules that highly accumulate around the soma of neurons. The components of the ECM in the CNS include proteins, proteoglycans, and glycosaminoglycans. Although hyaluronic acid (HA) is considered a constituent element of PNNs, the distribution of HA in the cortex has not been clarified. To elucidate the cortical region-specific distribution of HA, we quantitatively analyzed HA binding protein (HABP)-positive PNNs in the mature mouse cerebral cortex. Our findings revealed that HABP-positive PNNs are present throughout the mouse cortex. The distribution of many HABP-positive PNNs differed from that of Wisteria floribunda agglutinin-positive PNNs. Furthermore, we observed granular-like HABP-positive PNNs in layer 1 of the cortex. These findings indicate that PNNs in the mouse cortex show region-dependent differences in composition. HABP-positive PNNs in layer 1 of the cortex may have different functions such as neuronal differentiation, proliferation, and migration unlike what has been reported for PNNs so far.
Keywords
proteoglycansretrosplenial dysgranular cortexWFAECMHABPhyaluronic acid binding proteinS1BFPRHMPTANIHAUVDLOV1bLptAectorhinal cortexV2LV2MMRSGcRSDECTAu1PNNPBSAudFRAHyaluronic acidPerineuronal netCNScentral nervous systeminfralimbic cortexTemporal association cortexFrontal association cortexlateral orbital cortexdorsolateral orbital cortexVentral orbital cortexprimary motor cortexsecondary motor cortexprimary auditory cortexperirhinal cortexdorsal peduncular cortexprelimbic cortexSecondary somatosensory cortexNational Institutes of HealthExtracellular matrixPhosphate-buffered salineWisteria floribunda agglutininTEAcingulate cortexGlycosaminoglycans
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Authors
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara,