Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8840013 | Current Opinion in Neurobiology | 2018 | 8 Pages |
Abstract
The complexity and precision of cortical circuitries is achieved during development due to the exquisite diversity of synapse types that is generated in a highly regulated manner. Here, we review the recent increase in our understanding of how synapse type-specific molecules differentially regulate the development of excitatory and inhibitory synapses. Moreover, several synapse subtype-specific molecules have been shown to control the targeting, formation or maturation of particular subtypes of excitatory synapses. Because inhibitory neurons are extremely diverse, a similar molecular diversity is likely to underlie the development of different inhibitory synapses making it a promising topic for future investigation in the field of the synapse development.
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Authors
Emilia Favuzzi, Beatriz Rico,