Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8840056 | Current Opinion in Neurobiology | 2018 | 6 Pages |
Abstract
Gamma oscillations (â¼25-100âHz) are believed to play a role in cognition. Accordingly, aberrant gamma oscillations have been observed in several cognitive disorders, including Alzheimer's disease and Fragile X syndrome. Here, we review how recent results showing abnormal gamma rhythms in Alzheimer's disease and Fragile X syndrome help reveal links between cellular disturbances and cognitive impairments. We also discuss how gamma results from rodent models of Alzheimer's disease and Fragile X syndrome may provide insights about unique functions of distinct slow (â¼25-50âHz) and fast gamma (â¼55-100âHz) subtypes. Finally, we consider studies employing brain stimulation paradigms in Alzheimer's disease and discuss how such studies may reveal causal relationships between gamma impairments and memory disturbances.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Alexandra J Mably, Laura Lee Colgin,