Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8841070 | Neuroscience | 2018 | 52 Pages |
Abstract
Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction, social communication, and repetitive and stereotyped behaviors. Recent work has begun to explore geneâ¯Ãâ¯environmental interactions in the etiology of ASD. We previously reported that prenatal stress exposure in stress-susceptible heterozygous serotonin transporter (SERT) KO pregnant dams in a mouse model resulted in autism-like behavior in the offspring (SERT/S mice). The association between prenatal stress and ASD appears to be affected by maternal SERT genotype in clinical populations as well. Using the mouse model, we examined autistic-like behaviors in greater detail, and additionally explored whether diet supplementation with docosahexaenoic acid (DHA) may mitigate the behavioral changes. Only male SERT/S mice showed social impairment and stereotyped behavior, and DHA supplementation ameliorated some of these behaviors. We also measured monoamine levels in the SERT/S mice after three treatment paradigms: DHA-rich diet continuously from breeding (DHA diet), DHA-rich diet only after weaning (CTL/DHA diet) and control diet only (CTL diet). The dopamine (DA) content in the striatum was significantly increased in the SERT/S mice compared with wild-type (WT) mice, whereas no difference was observed with noradrenaline and serotonin content. Moreover, DA content in the striatum was significantly reduced in the SERT/S mice with the DHA-rich diet provided continuously from breeding. The results indicate that autism-associated behaviors and changes in the dopaminergic system in this setting can be mitigated with DHA supplementation.
Keywords
5-hydroxytryptamineDHBAPUFAs5HIAADOPAC5HTEPMGlc3,4-dihydroxybenzylamine3,4-dihydroxyphenylacetic acid5-Hydroxyindoleacetic acidHETAutism spectrum disorderStressArachidonic aciddocosahexaenoic acidFatty acidPolyunsaturated fatty acidsAutismelevated plus mazeDopamineDHASERTASDnorepinephrinewild typeheterozygousHPLChigh-performance liquid chromatographygas–liquid chromatography
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Fumihiro Matsui, Patrick Hecht, Kanji Yoshimoto, Yoshihisa Watanabe, Masafumi Morimoto, Kevin Fritsche, Matthew Will, David Beversdorf,