| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8841253 | Neuroscience | 2017 | 40 Pages |
Abstract
Thus these data suggest that Ccl2, Edn1, Tgfβ2, Olr1 and Serpine1 may be possible mediators of the vascular changes in the occluded MCAs from both SHRs and WKY rats after tMCAO. The aforementioned genes possess biological functions that are consistent with early stroke injuries. In conclusion, these genes may be potential targets in future strategies for acute stroke treatments that can be used in patients with and without hypertension.
Keywords
SERPINE1JAK2ICAM1CCL2cRNASHRsMMP9Janus Kinase 2MCASMABPEDN1HIF1αOLR1TIMP1chemokine (CC motif) ligand 2IVTTGFβ2ss-cDNAqPCRCBFFDRIQRGAPDHSAMQuantitative PCRactin betaendothelin 1Significance Analysis of Microarraysfold changecerebral blood flowIn vitro transcriptionBBBActbmean arterial blood pressureMatrix metalloproteinase 9bloodbrain barrierinterquartile rangeSpontaneously hypertensive ratsIntercellular adhesion molecule 1false discovery rateGene ontologythreshold cycleglyceraldehyde-3-phosphate dehydrogenase
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Authors
Anne-Sofie Grell, Maryam Mostajeran, Simona Denise Frederiksen, Lars Edvinsson, Saema Ansar,