Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8841336 | Neuroscience Letters | 2018 | 26 Pages |
Abstract
Chronic nicotine intake may contribute to dependence by overstimulating opiate receptors through release of opiate peptides. By analogy to opiate dependence, it was hypothesized that FF1 receptor activation contributes to nicotine dependence and withdrawal syndrome. AC-262620 significantly reduced somatically expressed withdrawal signs precipitated by the nicotinic antagonist mecamylamine in rats infused for seven days with nicotine bitartrate. Taken together, these findings suggest that NPFF or related neuropeptides contribute to opiate, as well as nicotine, dependence and withdrawal syndrome through the FF1 receptor.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
David H. Malin, Mallori M. Henceroth, Joanne Elayoubi, Joseph R. Campbell, Andrea Anderson, Pilar Goyarzu, Jonathan Izygon, Caitlin A. Madison, Christopher P. Ward, Ethan S. Burstein,