Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8841745 | Neuroscience Letters | 2018 | 24 Pages |
Abstract
Stuttering is a neurodevelopmental speech disorder with a phenotype characterized by speech sound repetitions, prolongations and silent blocks during speech production. Developmental stuttering affects 1% of the population and 5% of children. Neuroanatomical abnormalities in the major white matter tracts, including the arcuate fasciculus, corpus callosum, corticospinal, and frontal aslant tracts (FAT), are associated with the disorder in adults who stutter but are less well studied in children who stutter (CWS). We used deterministic tractography to assess the structural connectivity of the neural network for speech production in CWS and controls. CWS had higher fractional anisotropy and axial diffusivity in the right FAT than controls. Our findings support the involvement of the corticostriatal network early in persistent developmental stuttering.
Keywords
ROIPPVTDeterministic tractographyDTISSIAWSCWSCStaxial diffusivityMagnetic Resonance Imaging (MRI)radial diffusivityAdults who stutterPeabody Picture Vocabulary Testdiffusion tensor imagingDiffusion tensor imaging (DTI)Speech productionSMAcorticospinal tractDevelopmental stutteringmean diffusivitysupplementary motor arearegion of interestFrontal aslant tractfractional anisotropyFatMotor control
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Authors
Ehsan Misaghi, Zhaoran Zhang, Vincent L. Gracco, Luc F. De Nil, Deryk S. Beal,