Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8842173 | Progress in Neurobiology | 2018 | 75 Pages |
Abstract
Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes enwrap the neuronal components of the tripartite synapse, and due to this close interaction they are perfectly positioned to modulate neuronal communication. The interaction between astrocytes and synapses is facilitated by cell adhesion molecules and matricellular proteins, which have been implicated in the formation and functioning of tripartite synapses. The importance of such neuron-astrocyte integration at the synapse is underscored by the emerging role of astrocyte dysfunction in synaptic pathologies such as autism and schizophrenia. Here we review astrocyte-expressed cell adhesion molecules and matricellular molecules that play a role in integration of neurons and astrocytes within the tripartite synapse.
Keywords
FGFRIP3NMJGLASTPSD-95CSPGNMDARGPiTGFECMPDZVGCCconnexinsNCAMmEPSCglial glutamate transporterSyndecanHSPGFibronectin IIILRRSPARCN-methyl-D-aspartate glutamate receptorSynCAMGnRHgamma-aminobutyric acid receptorTN-CAMOGNeuron-glia interactionsSynaptogenesisTSPvWFACMSDCRGDPSARGCGPCDRGAMPAREGFdorsal root ganglioninositol 1,4,5-trisphosphateNeuroligintenascin-Cα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorAstrocytesNeuromuscular junctionPolysialic acidlong term depressiontransforming growth factorThrombospondinlong term potentiationLTPContactinneurodevelopmentLeucine-rich repeatsminiature excitatory postsynaptic currentImmunoglobulin superfamilyextracellular domainCNSAMIGOCAMretinal ganglion cellcentral nervous systemtripartite synapseepidermal growth factorVon Willebrand factorExtracellular matrixLTDastrocyte-conditioned mediumcell adhesion moleculesCell adhesion moleculeneural cell adhesion moleculeKnockdownknockoutSynapseGonadotropin-releasing hormoneHeparan sulfate proteoglycansecreted protein acidic and rich in cysteinecontactin-associated proteinpostsynaptic density protein 95PentraxinCASKvoltage-gated calcium channelchondroitin sulfate proteoglycanconnexinGABARGlypicanglycosylphosphatidylinositolfibroblast growth factor receptor
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Authors
Anne E.J. Hillen, J. Peter H. Burbach, Elly M. Hol,