Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8842174 | Progress in Neurobiology | 2018 | 69 Pages |
Abstract
Several studies have indicated that certain misfolded amyloids composed of tau, β-amyloid or α-synuclein can be transferred from cell to cell, suggesting the contribution of mechanisms reminiscent of those by which infective prions spread through the brain. This process of a 'prion-like' spreading between cells is also relevant as a novel putative therapeutic target that could block the spreading of proteinaceous aggregates throughout the brain which may underlie the progressive nature of neurodegenerative diseases. The relevance of β-amyloid oligomers and cellular prion protein (PrPC) binding has been a focus of interest in Alzheimer's disease (AD). At the molecular level, β-amyloid/PrPC interaction takes place in two differently charged clusters of PrPC. In addition to β-amyloid, participation of PrPC in α-synuclein binding and brain spreading also appears to be relevant in α-synucleopathies. This review summarizes current knowledge about PrPC as a putative receptor for amyloid proteins and the physiological consequences of these interactions.
Keywords
CREBBSECWDNADPHAβEGCGMSACNOAPPCaMKIIpKaHEK293MPTPNMDAp75NTRGSK3α7nAChRDLBGPicAMP response binding proteinDREADDSOD1NFTGSSPYK2NR2BGRP78β-ARsN2amGluR5CC1CC2CJDPrPcPrPresLAG3lymphocyte-activation gene 3FcγRIIbFFIAPLP1sCJDPHFPrPscSporadic Creutzfeldt-Jakob diseasevCJDSTI1Proto-oncogene tyrosine-protein kinasescrapie prion proteinEF2Gerstmann-Sträussler-Scheinker syndrome(−)-Epigallocatechin-3-gallateERK1/2HSPGsiPSMAPKMdm2ROSβ-AmyloidMultiple system atrophyAmyloidamino acidamyotrophic lateral sclerosisLewy bodiesFatal familial insomniaCreutzfeldt-Jakob diseaseAlzheimer’s diseaseALSChronic wasting diseaseParkinson’s diseaseDementia with Lewy bodiesNeurodegenerationTnTBovine spongiform encephalopathyCNSAβoPaired helical filamentsinduced pluripotent stemhuman embryonic kidney cell lineNeuroblastoma cell linesuperoxide dismutase 1central nervous systemElongation factor 2Lewy neuritesFynneurofibrillary tanglesvariant CJDnicotinamide adenine dinucleotide phosphateHematoxylin and Eosincalmodulin-dependent protein kinase IISpreadingamyloid precursor proteinprotein kinase Amitogen-activated protein kinasecellular prion proteinheparan sulfate proteoglycansPirBClozapine-N-Oxideglucose regulated protein 78glycosylphosphatidylinositolglycogen synthase kinase 3Reactive oxygen speciesα7 nicotinic acetylcholine receptorp75 neurotrophin receptorβ-adrenergic receptorsdesigner receptors exclusively activated by designer drugsmetabotropic glutamate receptor 5
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Authors
José A. del RÃo, Isidre Ferrer, Rosalina GavÃn,