Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8842180 | Progress in Neurobiology | 2018 | 76 Pages |
Abstract
Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke. In this review, we compile miRNAs that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of miRNAs in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis. Since promoting or suppressing expression of miRNAs by specific pharmaceutical and non-pharmaceutical therapies may be beneficial to post-stroke recovery, we also highlight the potential therapeutic value of miRNAs in clinical settings.
Keywords
NF-κBTNFαIL-6miRNAsMYD88Nrf2BMSCsMcl-1MMP-9ERKABCA1AquaporinsAMPAhs-CRPOGDNMDAGLT-1N-methyl-d-aspartateMCAOAAVAT1RHMGB1SVZα-amino-3-hydroxy-5-methyl-4-isoxazole propionateSAHSHRsNMDA receptor subunit 2BVNS3-NTNIHSSGluR2NR2BGRP78IL-1RZO-1Bcl-6pri-miRNAATP-binding cassette transporter 1Cdc25aAQPsPPAR-δprimary miRNAsprecursor miRNAsHIF1-αIRAK4RE1-silencing transcription factorLNASGlutamate receptor 2cell division cycle 25AInterleukin-1 receptor-associated kinase 4NCOA13-nitrotyrosineCdk6Myeloid cell leukemia-1Mn-SODROSAtherosclerosisArgonauteangiotensin II type 1 receptorLocked nucleic acidsmiddle cerebral artery occlusioninterleukin 6ReSTDiabetesvagus nerve stimulationtumor necrosis factor alphaRISCintracerebral hemorrhageSubarachnoid hemorrhageShhCNSmicroRNAsBBBBlood–brain barriermanganese superoxide dismutaseStrokecentral nervous systemdentate gyrushypoxia-inducible factor 1 alphamyeloid differentiation factor 88nuclear factor erythroid 2-related factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor kappa BHypertensionMatrix metalloproteinase-9Cerebrospinal fluidCSFRNA-Induced Silencing ComplexOxygen and glucose deprivationICHsubventricular zoneNational Institute of Health Stroke ScaleSpontaneously hypertensive ratsZonula occludens-1Nitric oxideAdeno-associated virusglucose-regulated protein 78high-sensitivity C-reactive proteinAGOpre-miRNAsPreconditioningextracellular signal-related kinasehigh mobility group box-1glutamate transporter 1active oxygen speciesinterleukin-1 receptor
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Authors
Guangwen Li, Kahlilia C. Morris-Blanco, Mary S. Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin Luo,