Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8842211 | Progress in Neurobiology | 2017 | 25 Pages |
Abstract
New players are emerging in the game of peripheral and central nervous system injury since their physiopathological mechanisms remain partially elusive. These mechanisms are characterized by several molecules whose activation and/or modification following a trauma is often controlled at transcriptional level. In this scenario, microRNAs (miRNAs/miRs) have been identified as main actors in coordinating important molecular pathways in nerve or spinal cord injury (SCI). miRNAs are small non-coding RNAs whose functionality at network level is now emerging as a new level of complexity. Indeed they can act as an organized network to provide a precise control of several biological processes. Here we describe the functional synergy of some miRNAs in case of SCI and peripheral damage. In particular we show how several small RNAs can cooperate in influencing simultaneously the molecular pathways orchestrating axon regeneration, inflammation, apoptosis and remyelination. We report about the networks for which miRNA-target bindings have been experimentally demonstrated or inferred based on target prediction data: in both cases, the connection between one miRNA and its downstream pathway is derived from a validated observation or is predicted from the literature. Hence, we discuss the importance of miRNAs in some pathological processes focusing on their functional structure as participating in a cooperative and/or convergence network.
Keywords
CREBPI3KIL-6JnkIL-1p53DRGMRFGFAPMBPFASmTORRhoANF-kBBcl-2MAGLNAAPCOLSIL-1βNGFMCAORac1Mecp2FGF2NSCsSOD1IKKFADDrAAVATF3NPCEgr2PAKGAP-43IL-1αIRAK1NCAMSmad3Sox2MAP1BHes5Smad2DGCR8DiGeorge syndrome critical region 8FGFR2SOX4RVGSPCsNeuroD1p73DLKHSPB1Fas-LROCK1PRKAG3FGF9SMACRE1-silencing transcription factorIkBαNEUROG2p21-Activated kinasesFOXJ3Fap-1CAND1Sox6LIFDickkopf-related protein 1Neuronal progenitor cellMothers against decapentaplegic homolog 3SRY-Box 2PMP-22recombinant AAVdorsal root ganglionBDNFc-Jun N-terminal kinaseDkk-1MAPKp53 upregulated modulator of apoptosisOPCsSmall interfering RNASCZsiRNAspinal muscular atrophyADAMadenomatous polyposis coliSpinal cord injurybranched chain amino acidsbranched-chain aminotransferaseAktSchizophreniadocosahexaenoic acidLocked Nucleic Acidmiddle cerebral artery occlusioninterleukin 1interleukin 1αinterleukin 1βinterleukin 6ReSTLentiviral vectorsBCAAa disintegrin and metalloproteasetumor protein p53forkhead Box ORISCSMAdual leucine zipper kinasesecond mitochondria-derived activator of caspasesDHAgrowth associated protein 43Ras-related C3 botulinum toxin substrate 1BBBblood brain barrierOligodendrocyte progenitor cellsNeural stem cellssuperoxide dismutase 1fibroblast growth factor 2Fibroblast growth factor 9leukemia inhibitory factorRas homolog gene family member Ascinerve growth factorBrain-derived neurotrophic factornuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alphanuclear factor kappa BFoxOPhosphoinositide 3-kinasesactivating transcription factor 3B-cell lymphoma 2RNA-Induced Silencing Complexneural cell adhesion moleculeNeurogenin 2Mechanistic target of rapamycinrabies virus glycoproteinEarly growth response 2cAMP response element binding proteinmethyl CpG binding protein 2Fas-associated protein with death domainMyelin basic proteinprotein kinase Bmitogen-activated protein kinasePeripheral myelin protein 22PUMAPtenMyelin-associated glycoproteinfibroblast growth factor receptor 2oligodendrocytes
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Authors
M. Ghibaudi, M. Boido, A. Vercelli,