Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8850005 | Saudi Journal of Biological Sciences | 2018 | 4 Pages |
Abstract
This study investigated the susceptibility of female C57Bl/6 and Swiss Albino mice to oxidative stress and neurotransmitters activity induced by Plasmodium berghei. On day 9 p.i. with P. berghei infected erythrocytes, the mice reduced in weight. This weight loss was markedly higher in SW mice and reached about â14%. Also, the infection was able to cause oxidative damage to the brain tissue. Catalase activity as well as glutathione, malondialdehyde and nitric oxide levels were different in the two mice strains. Moreover, the brain content of neurotransmitters, epinephrine, norepinephrine, dopamine and serotonin in mice brain was higher in SW mice than B6 mice. We concluded that, the strain of mice is one factor that could alter the response of mice to P. berghei infection.
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Authors
Esam M. Al-Shaebi, Walid F. Mohamed, Saleh Al-Quraishy, Mohamed A. Dkhil,