Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8850070 | Saudi Journal of Biological Sciences | 2017 | 6 Pages |
Abstract
Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (Pâ¯<â¯.05) were noted with 20â¯mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20â¯mg/kg) meaningfully (Pâ¯<â¯.05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20â¯mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (Pâ¯<â¯.05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities.
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Authors
Paulrayer Antonisamy, Muniyappan Dhanasekaran, Ha-Rim Kim, Sung-Gang Jo, Paul Agastian, Kang-Beom Kwon,