Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8852829 | Chemosphere | 2018 | 37 Pages |
Abstract
An analytical method has been developed for the trace determination of 10 dechlorane-related compounds (DRCs) in food products by gas chromatography - high resolution mass spectrometry (GC-HRMS). The highest sensitivity of this instrumental analysis method was achieved by selection of the GC column type, optimization of the heated zones within the instrument, and adjusting the electron impact energy. The efficiency of solid phase extraction as clean-up procedure was also optimized. Two different types of cartridges - neutral silica gel and Florisil®, as well as seven organic solvents or their mixtures - n-hexane, cyclohexane, acetone, toluene, n-hexane/ethyl acetate, n-hexane/acetone, and n-hexane/dichloromethane - were evaluated. The analytical method was characterized as selective, precise, accurate, and linear over the concentration ranges from 1.00 to 100 pg μLâ1 for DRCs. Ultra-trace level sensitivity was achieved with the instrumental limits of quantification (i-LOQs) varying from â¼0.01 pg to â¼Â 1 pg and method limits of quantification (m-LOQs) by the analysis of 10 g of sample varying from â¼0.04 to â¼Â 5 pg gâ1. The developed method was successfully applied for the analysis of food samples and the analyses revealed the presence of majority of selected DRCs, with the Dechlorane Plus (DP) isomers occurring to a greater extent, pointing to the highest levels in cod liver and other fish products.
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Authors
Jekaterina Rjabova, Arturs Viksna, Dzintars Zacs,