| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8853562 | Ecotoxicology and Environmental Safety | 2018 | 7 Pages |
Abstract
Potential mechanism of luteolin in HgCl2-induced heart injury. Luteolin protected against HgCl2-induced heart injury by alleviating oxidative stress and apoptosis through increased levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor-erythroid-2-related factor 2 (Nrf2) and its downstream proteins, and inhibited NF-κB activation.317
Keywords
IκBnuclear factor-erythroid-2-related factor 2MDAHgCl2inhibitory kappa BCK-MBNQO1Heme oxygenase-1LUTGSSGHO-1Nrf2NF-κBPI3KGSHkeap1NAD(P)H Quinone Oxidoreductase 1p-AktROSCardiac damageAkttumor necrosis factor αApoptosisTNF-αNuclear factor-kappa Bphospho-AktPhosphatidylinositol 3-kinaseLuteolinmalonyldialdehydeKelch-like ECH-associated protein 1protein kinase Breduced glutathioneCreatine kinaseMercuric chlorideoxidized glutathioneReactive oxygen species
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Authors
Ruiqi Baiyun, Siyu Li, Biying Liu, Jingjing Lu, Yueying Lv, Jianwen Xu, Jiahui Wu, Jiayi Li, Zhanjun Lv, Zhigang Zhang,