Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8855163 | Environment International | 2018 | 9 Pages |
Abstract
In single-POP models, significant associations were detected between OCP measurements and placental DNA methylation. Elevated concentrations of β-hexachlorhexane (β-HCH) in maternal serum collected during delivery were significantly associated with a decrease in methylation of LINE-1 in the placenta. Higher levels of p,pâ²-dichlorodiphenyltrichloroethane (p,pâ²-DDT) in maternal serum were associated with hypermethylation of insulin-like growth factor 2 (IGF2). In multiple-POP models, a significant and positive association between DDTs and IGF2 methylation was also observed. Placental LINE-1 methylation was inversely associated with birth length. Our observations indicate that prenatal exposure to several POPs including DDTs is associated with the changes in methylation of genes, including major imprinted genes in the placenta. The consequences of these epigenetic alterations in placenta during development deserve further investigation.
Keywords
Trans-nonachlordaneIGF2IQRp,p′-dichlorodiphenyldichloroethylenePBDEsHCHPCBsp,p′-dichlorodiphenyltrichloroethaneLOQOCPsPCAp,p′-DDEOrganochlorine pesticidesPersistent organic pollutantPOPsPersistent organic pollutantsstandard deviationEpigeneticsPolychlorinated biphenylsPrincipal component analysisLINE-1Polybrominated diphenyl ethersFetal growthbody mass indexBMIp,p′-DDTLong interspersed element-1confidence intervalinsulin-like growth factor 2Global methylationinterquartile rangelimit of quantificationHexachlorocyclohexaneImprinted gene
Related Topics
Life Sciences
Environmental Science
Environmental Chemistry
Authors
Sujin Kim, Yoon Hee Cho, Inae Lee, Wonji Kim, Sungho Won, Ja-Lok Ku, Hyo-Bang Moon, Jeongim Park, Sungkyoon Kim, Gyuyeon Choi, Kyungho Choi,