Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels

Article ID	Journal	Published Year	Pages	File Type
8855476	Environment International	2018	13 Pages	PDF

Abstract

Our data suggest that prenatal and mid-childhood PFAS exposure may be associated with modest, but somewhat conflicting changes in the lipid profile and ALT levels in children.

Keywords

ALT HDL-C PFHxS perfluorooctane sulfonamide GFR IQR PFAS perfluorohexane sulfonate PPAR LDL-C GAM PFNA CDC PFOS PFOA perfluorodecanoate PFOSA perfluorononanoate NAFLD Alanine aminotransferase Pregnancy Nonalcoholic fatty liver disease Triglycerides LOD یا Limit of detection Childhood Perfluorooctane sulfonate body mass index BMI Liver function confidence interval Perfluorooctanoate high-density lipoprotein cholesterol interquartile range limit of detection Generalized additive models Centers for Disease Control and Prevention per- and polyfluoroalkyl substances Glomerular filtration rate Lipids total cholesterol Low-density lipoprotein cholesterol peroxisome proliferator-activated receptor

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Life Sciences Environmental Science Environmental Chemistry

Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels

Authors

Ana M. Mora, Abby F. Fleisch, Sheryl L. Rifas-Shiman, Jennifer A. Woo Baidal, Larissa Pardo, Thomas F. Webster, Antonia M. Calafat, Xiaoyun Ye, Emily Oken, Sharon K. Sagiv,