Biomarkers of exposure in environment-wide association studies - Opportunities to decode the exposome using human biomonitoring data

Article ID	Journal	Published Year	Pages	File Type
8868934	Environmental Research	2018	28 Pages	PDF

Abstract

Data about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline - snapshot in time without any claim to comprehensiveness - to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.

Keywords

BPA nDMA GGT IL-6 PGA SHS PFC PAH POD ECO STA PSS tetrabromobisphenol A AAS PCB PFOA PFOS THMs CyP DBP ICC BPP MBP PBDE FAS Citrinin DAP MEP CPK PCP DMP DEP DIBP Deoxynivalenol MHA BAT FFQ OTA MCT HCB dichlorodiphenyltrichloroethane TCDD DBPs DBA HBCDD DnBP 3-phenoxybenzoic acid dialkylphosphate DCCA DEHP DETP MnBP mono-n-butyl phthalate DMTP MBzP HBM DINCH 5Oxo-MEHP BFRs DMDTP di-n-butyl phthalate PCDD CIT PCDF CYP1A1 DDE dichlorodiphenyldichloroethylene TBBPA TLV Threshold Limit Values MRL RfD BzBP BDCM TDI DBCM BPS RFC MAA IMD MOA BPF UVR EWAS APGAR pg/ml LOAEL NOAEL PYR IPAQ MEHP NNAL NNK PBBK DEDTP dimethyl thiophosphate UFPs HEALS 5OH-MEHP DEHT β-HCH β-hexachlorocyclohexane 1-HP BPAD OPPs ALARP third-hand smoke Di(2-ethylhexyl) terephthalate S-PMA GPAQ Family affluence scale N-nitrosoproline NtcA MiNP TCAA Trihalomethanes MEHHP MEOHP N-nitrososarcosine mono(2-ethyl-5-hydroxyhexyl) phthalate systemic exposure dose μg/L P90 AAMA P95 U/L 1-hydroxypyrene 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 7-Methylguanine Polychlorinated dibenzofurans DiNP DNA emf BAC mono(2-ethyl-5-oxohexyl) phthalate mono-(2-ethylhexyl) phthalate mVOC N-nitrosodimethylamine ADI NOx NPs OCPs Tetrachlorodibenzo-p-dioxin THs γ-Glutamyl transferase Arsenic Alcohol Use Disorders Identification Test Organochlorine pesticides Organophosphate pesticides POPs Persistent organic pollutants SES Iron reference value Stachybotrys chartarum deoxyribonucleic acid Perfluorooctanesulfonic acid trichloroacetic acid Phenylglyoxylic acid Methylhippuric acid Ultraviolet radiation standard deviation Sample size Ozone Ochratoxin A Nitrogen oxides United States interleukin-6 NSAR Brominated flame retardants Bromodichloromethane BoE benzylbutyl phthalate As Low As Reasonably Practicable butylbenzyl phthalate Bisphenol F bisphenol S Bisphenol A polybrominated biphenyls Polychlorinated biphenyl Biomarker of exposure biomarkers of exposure Human biomonitoring N-nitroso compounds Perfluorinated compounds Microbial volatile organic compounds Total JEM Mercury Mode of action Minimal risk level Audit per Acceptable daily intake decibel Second-hand smoke Reference dose DON Diethyl phthalate diethyl dithiophosphate di-iso-butyl phthalate Polychlorinated dibenzo-p-dioxins dimethyl phosphate Dibromochloromethane diisononyl phthalate DDT particulate matter Radon Food and Agriculture Organization PBB hours Lead Selenium cytochrome P450 1A1 Cytochrome P450 Index of Multiple Deprivation NOC 95th percentile Disinfection by-products intraclass correlation coefficient Number Alkylating agents Critical concentration Reference concentration FAO pharmacokinetic Zinc State-Trait Anxiety Inventory lactate dehydrogenase LDH mono-ethyl phthalate Blood alcohol content GAMA Benchmark dose lower confidence limit Copper Tolerable daily intake GWAS Biomonitoring equivalents Reference values Perceived Stress Scale Manganese PTWI monobenzyl phthalate monobutyl phthalate mono-isononyl phthalate Arithmetic mean Geometric mean Electromagnetic field Nanoparticles Point of departure No.Npro Provisional Tolerable Weekly Intake Hexabromocyclododecane Polycyclic aromatic hydrocarbon No observed adverse effect level sed socioeconomic status BEI United Kingdom food frequency questionnaires Perfluorooctanoic acid C-reactive protein CRP Pyrene Cadmium Creatine phosphokinase creatinine Chromium Lowest observed adverse effect level