Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8868937 | Environmental Research | 2018 | 7 Pages |
Abstract
B. licheniformis was cytotoxic to NuLi-1 cells at 24â¯h. At 3â¯h post-challenge, B. licheniformis elicited high IL-6 and IL-8 inflammatory responses from NuLi-1 cells compared with cells treated with heat-treated geogenic dust PM10 (pâ¯<â¯0.0001). Whilst treatment of cells with B. licheniformis increased inflammation, this did not make the cells more susceptible to NTHi infection. This study highlights that geogenic dust PM10 can harbour viable bacterial spores that induce inflammation in respiratory epithelium. The impact on respiratory health from inhalation of bacterial spores in PM10 in arid environments may be underestimated. Further investigation into the contribution of B. licheniformis and the wider dust microbiome to respiratory infection is warranted.
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Authors
Janessa Pickering, Teck Hui Teo, Ruth B. Thornton, Lea-Ann Kirkham, Graeme R. Zosky, Holly D. Clifford,