Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8922453 | Clinical and Translational Radiation Oncology | 2017 | 8 Pages |
Abstract
These results indicate that blocking the IGF-1R-mediated signaling cascade, through the expression of a kinase-deficient IGF-1R mutant, reduces cell growth and sensitizes cancer cells to ionizing radiation. Therefore, the IGF-1R system could be a potential target to enhance radio-sensitivity and the efficacy of cancer treatments.
Keywords
HRRNHEJBcl-2RadiosensitivityBcl-2-associated XBRCA2IRS-1IGF-1RMVPBaxHomologous recombination repairDominant negative mutantinsulin receptor substrate 1non-homologous end joiningphosphatase and tensin homologB-cell lymphoma 2major vault proteinPtenInsulin-like growth factor-1 receptorinsulin-like growth factor 1 receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Senthiladipan Venkatachalam, Esther Mettler, Christian Fottner, Matthias Miederer, Bernd Kaina, Matthias M. Weber,