| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8923802 | Neurobiology of Pain | 2018 | 9 Pages |
Abstract
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We hypothesized that PB hyperactivity influences chronic pain behavior after trigeminal nerve injury in rats. Following induction of neuropathic pain using the chronic constriction injury of the infraorbital nerve (CCI-ION) model, rats displayed spontaneous markers of pain and mechanical hyperalgesia extending beyond the receptive field of the injured nerve. PB neurons recorded from rats with CCI-ION displayed amplified activity, manifesting as significantly longer responses to sensory stimuli, compared to shams. These findings suggest that chronic neuropathic pain involves PB hyperactivity.
Keywords
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Olivia Uddin, Paige Studlack, Titilola Akintola, Charles Raver, Alberto Castro, Radi Masri, Asaf Keller,