Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits

Article ID	Journal	Published Year	Pages	File Type
8929750	British Journal of Anaesthesia	2018	16 Pages	PDF

Abstract

Inhibition of RhoA prevents propofol-mediated hippocampal neurotoxicity and associated cognitive deficits.

Keywords

Axonal transport Synapses Growth cone Hippocampus

Related Topics

Health Sciences Medicine and Dentistry Anesthesiology and Pain Medicine

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Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits

Authors

M.L. Pearn, J.M. Schilling, M. Jian, J. Egawa, C. Wu, C.D. Mandyam, M.J. Fannon-Pavlich, U. Nguyen, J. Bertoglio, M. Kodama, S.K. Mahata, C. DerMardirossian, B.P. Lemkuil, R. Han, W.C. Mobley, H.H. Patel, P.M. Patel, B.P. Head,