Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8929751 | British Journal of Anaesthesia | 2018 | 10 Pages |
Abstract
Mean arterial plasma concentrations of dexmedetomidine in infants and toddlers approached 100 pg mlâ1, the low end reported for sedative efficacy, within 20 min of an atomised intranasal administration of 1 μg kgâ1. Doubling the dose to 2 μg kgâ1 reached this plasma concentration within 10 min and achieved almost twice the peak concentration. Peak plasma concentrations with both doses were reached within 47 min of intranasal administration, with an overall bioavailability of 84%.
Related Topics
Health Sciences
Medicine and Dentistry
Anesthesiology and Pain Medicine
Authors
J.W. Miller, R. Balyan, M. Dong, M. Mahmoud, J.E. Lam, J.N. Pratap, J.R. Paquin, B.L. Li, J.P. Spaeth, A. Vinks, A.W. Loepke,