Article ID Journal Published Year Pages File Type
8929766 British Journal of Anaesthesia 2018 9 Pages PDF
Abstract
Acute repeated fentanyl administration dose-dependently produced mechanical hyperalgesia and augmented surgery induced postoperative hyperalgesia. This behavioural change was paralleled with an increase in spinal COX-2 mRNA and PGE2 after fentanyl administration. Inhibition of COX-2 or blockade of EP-1R can partly or totally prevent hyperalgesia.
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Health Sciences Medicine and Dentistry Anesthesiology and Pain Medicine
Preview
Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats
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