| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8930608 | British Journal of Anaesthesia | 2016 | 9 Pages |
Abstract
Intrathecal administration of LIF potentiated morphine antinociceptive activity and attenuated the development of morphine tolerance. Upregulation of endogenously released LIF by long-term use of opioids might counterbalance the tolerance induction effects of other proinflammatory cytokines. LIF might be a novel drug candidate for inhibiting opioid tolerance induction.
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Authors
H.J. Tu, K.H. Kang, S.Y. Ho, H.C. Liou, H.H. Liou, C.P. Lin, W.M. Fu,