Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8931387 | British Journal of Anaesthesia | 2015 | 8 Pages |
Abstract
At clinically relevant concentrations both ropivacaine and lidocaine blocked tumour cell invasion and MMP-9 secretion by attenuating Src-dependent inflammatory signalling events. Although determined entirely in vitro, these findings provide significant insight into the potential mechanism by which local anaesthetics might diminish metastasis.
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Authors
T. Piegeler, M. Schläpfer, R.O. Dull, D.E. Schwartz, A. Borgeat, R.D. Minshall, B. Beck-Schimmer,