Article ID Journal Published Year Pages File Type
8932084 British Journal of Anaesthesia 2015 8 Pages PDF
Abstract
Propofol depresses ventral horn interneurones predominantly by phasic rather than by tonic GABA(A) receptor-mediated inhibition. However, the present results suggest that the involvement of a tonic inhibition might contribute to the efficacy of propofol to depress nociceptive reflexes at high concentrations of the anaesthetic.
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Health Sciences Medicine and Dentistry Anesthesiology and Pain Medicine
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Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones
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