Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8933263 | British Journal of Anaesthesia | 2014 | 9 Pages |
Abstract
Epidural administration of methadone in rats resulted in systemic exposure similar to that after i.v. administration, but improved thermal antinociceptive efficacy, and reduced supraspinal undesired effects. The findings suggest the presence of local effect at the spinal cord level, in addition to the systemic effect produced by epidural methadone.
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Authors
S. Haroutiunian, L. Kagan, I. Yifrach-Damari, E. Davidson, Y. Ratz, A. Hoffman,